In Vitro and In Vivo Antibacterial Activities of Levofloxacin ( l -Ofloxacin), an Optically Active Ofloxacin
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چکیده
منابع مشابه
In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin.
The antibacterial activity of levofloxacin was compared with those of ofloxacin, ciprofloxacin, and other antibiotics. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all 801 organisms tested. Levofloxacin was twofold [corrected] more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin agains...
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Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (-)-ofloxacin, was 8 to 128 times more potent in inhibiting the multiplication ...
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Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1) [(•})ofloxacin; DL-8280; (•} )-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl1 -piperazinyl)-7-oxo-7Hpyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid] and their fluoromethyl derivatives (14a and 14b) were prepared via their optically active intermediates resolved by use of high-performance liquid chromatography...
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The in-vitro activity of levofloxacin was compared with ofloxacin and D-ofloxacin against 130 isolates of Staphylococcus aureaus and 117 isolates of coagulase-negative staphylococci, using the agar dilution method. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all staphylococci, including 61 methicillin-resistant S. aureus. In contrast, D-oflox...
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Tuberculosis remains one of the main problem worldwide and the emergence of MDR-M.tuberculosis strains has become a major concern.The decreased activity of first line drugs,especially to isoniazid and rifampin causes some problems in the treatment of MDR-tb. Compared with the other infections,drugs clinically active to M.tuberculosis relatively more fewer (1). Because of this reason alternative...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.8.1797